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Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity.

ABSTRACT: We found that the selective stimulation of the intracellular, transmembrane G protein-coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial blood vessels. Stimulation of GPER blocks vasoconstrictor-induced changes in intracellular calcium concentrations and vascular tone, as well as serum-stimulated cell proliferation of human vascular smooth muscle cells. Deletion of the GPER gene in mice abrogates vascular effects of GPER activation and is associated with visceral obesity. These findings suggest novel roles for GPER in protecting from cardiovascular disease and obesity.

SUBMITTER: Haas E

PROVIDER: S-EPMC2782532 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity.

Haas Elvira E Bhattacharya Indranil I Brailoiu Eugen E Damjanović Marlen M Brailoiu G Cristina GC Gao Xin X Mueller-Guerre Laurence L Marjon Nicole A NA Gut André A Minotti Roberta R Meyer Matthias R MR Amann Kerstin K Ammann Emerita E Perez-Dominguez Ana A Genoni Michele M Clegg Deborah J DJ Dun Nae J NJ Resta Thomas C TC Prossnitz Eric R ER Barton Matthias M

Circulation research 20090129 3

We found that the selective stimulation of the intracellular, transmembrane G protein-coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial blood vessels. Stimulation of GPER blocks vasoconstrictor-induced changes in intracellular calcium concentrations and vascular tone, as well as serum-stimulated cell proliferation of human vascular smooth muscle cells. Deletion of the GPER gene in mi ...[more]

PMID: 19179659

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