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Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots.

ABSTRACT: A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.

SUBMITTER: Choi HS

PROVIDER: S-EPMC2782558 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots.

Choi Hak Soo HS Ipe Binil Itty BI Misra Preeti P Lee Jeong Heon JH Bawendi Moungi G MG Frangioni John V JV

Nano letters 20090601 6

A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance ...[more]

PMID: 19422261

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