Ontology highlight
ABSTRACT:
SUBMITTER: Hirbe AC
PROVIDER: S-EPMC2782613 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Hirbe Angela C AC Roelofs Anke J AJ Floyd Desiree H DH Deng Hongju H Becker Stephanie N SN Lanigan Lisa G LG Apicelli Anthony J AJ Xu Zhiqiang Z Prior Julie L JL Eagleton Mark C MC Piwnica-Worms David D Rogers Michael J MJ Weilbaecher Katherine K
Bone 20090123 5
Bisphosphonates (BPs), bone targeted drugs that disrupt osteoclast function, are routinely used to treat complications of bone metastasis. Studies in preclinical models of cancer have shown that BPs reduce skeletal tumor burden and increase survival. Similarly, we observed in the present study that administration of the Nitrogen-containing BP (N-BP), zoledronic acid (ZA) to osteolytic tumor-bearing Tax+ mice beginning at 6 months of age led to resolution of radiographic skeletal lesions. N-BPs i ...[more]