Ontology highlight
ABSTRACT:
SUBMITTER: Ntukidem NI
PROVIDER: S-EPMC2782693 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20070822 5
Tamoxifen induces important changes in serum lipid profiles in some women; however, little information is available to predict which women will experience improved lipid profiles during tamoxifen therapy. As part of a multicenter prospective observational trial in 176 breast cancer patients, we tested the hypothesis that tamoxifen-induced lipid changes were associated with genetic variants in candidate target genes (CYP2D6, ESR1, and ESR2). Tamoxifen lowered low-density lipoprotein cholesterol ( ...[more]