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Prevalence of antitumor antibodies in laying hen model of human ovarian cancer.

ABSTRACT: Antitumor antibodies are associated with tumors in human cancers. There is relatively little information on the timing and progression of antibody response to tumors. The objective of the study was to determine if spontaneous ovarian cancer in the egg-laying hen is associated with antitumor antibodies. Antibodies were detected by immunoassay and immunoblotting using proteins from normal ovary and ovarian tumors. Candidate antigens were identified by mass spectrometry of immunoreactive spots cut from 2-dimensional gels and Western blot. Antitumor (serum reacting against tumor ovarian extract) and antiovarian (serum reacting against normal ovarian extract) antibodies were significantly associated with ovarian cancer (67%; P

SUBMITTER: Barua A

PROVIDER: S-EPMC2782776 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Prevalence of antitumor antibodies in laying hen model of human ovarian cancer.

Barua Animesh A Edassery Seby L SL Bitterman Pincas P Abramowicz Jacques S JS Dirks Angela L AL Bahr Janice M JM Hales Dale B DB Bradaric Michael J MJ Luborsky Judith L JL

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20090501 4

Antitumor antibodies are associated with tumors in human cancers. There is relatively little information on the timing and progression of antibody response to tumors. The objective of the study was to determine if spontaneous ovarian cancer in the egg-laying hen is associated with antitumor antibodies. Antibodies were detected by immunoassay and immunoblotting using proteins from normal ovary and ovarian tumors. Candidate antigens were identified by mass spectrometry of immunoreactive spots cut ...[more]

PMID: 19509543

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Selenium-Binding Protein 1 expression in ovaries and ovarian tumors in the laying hen, a spontaneous model of human ovarian cancer.

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Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer.

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Expression of Leukocyte Inhibitory Immunoglobulin-like Transcript 3 Receptors by Ovarian Tumors in Laying Hen Model of Spontaneous Ovarian Cancer.

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Chemopreventive effect of flaxseed-enriched diet on ovarian cancer in laying hen.

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Chemopreventive effect of flaxseed-enriched diet on ovarian cancer in laying hen.

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2015-05-18 | E-GEOD-40376 | biostudies-arrayexpress

Uncovering molecular events associated with the chemosuppressive effects of flaxseed: a microarray analysis of the laying hen model of ovarian cancer.

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