Ontology highlight
ABSTRACT:
SUBMITTER: Hampton CM
PROVIDER: S-EPMC2782859 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Hampton Cheri M CM Liu Jun J Taylor Dianne W DW DeRosier David J DJ Taylor Kenneth A KA
Structure (London, England : 1993) 20081201 12
Villin is an F-actin nucleating, crosslinking, severing, and capping protein within the gelsolin superfamily. We have used electron tomography of 2D arrays of villin-crosslinked F-actin to generate 3D images revealing villin's crosslinking structure. In these polar arrays, neighboring filaments are spaced 125.9 +/- 7.1 A apart, offset axially by 17 A, with one villin crosslink per actin crossover. More than 6500 subvolumes containing a single villin crosslink and the neighboring actin filaments ...[more]