Dealing with low pH: entry and exit of alphaviruses and flaviviruses.
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ABSTRACT:
SUBMITTER: Sanchez-San Martin C
PROVIDER: S-EPMC2783195 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
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Dealing with low pH: entry and exit of alphaviruses and flaviviruses.
Sánchez-San Martín Claudia C Liu Catherine Y CY Kielian Margaret M
Trends in microbiology 20090930 11
The alphaviruses and flaviviruses include many important human pathogens, such as the dengue, West Nile, and Chikungunya viruses. These enveloped viruses infect cells by a membrane fusion reaction triggered by the low pH in endosomes. Fusion is mediated by viral membrane proteins through their acid-dependent conversion from a dimer on the virus surface to a homotrimer inserted into the host cell membrane. Here we review recent studies on the regulatory mechanisms that silence these fusion protei ...[more]
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