The role of integrin alpha8beta1 in fetal lung morphogenesis and injury.
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ABSTRACT:
SUBMITTER: Benjamin JT
PROVIDER: S-EPMC2783258 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Publications
The role of integrin alpha8beta1 in fetal lung morphogenesis and injury.
Benjamin John T JT Gaston David C DC Halloran Brian A BA Schnapp Lynn M LM Zent Roy R Prince Lawrence S LS
Developmental biology 20090919 2
Prenatal inflammation prevents normal lung morphogenesis and leads to bronchopulmonary dysplasia (BPD), a common complication of preterm birth. We previously demonstrated in a bacterial endotoxin mouse model of BPD that disrupting fibronectin localization in the fetal lung mesenchyme causes arrested saccular airway branching. In this study we show that expression of the fibronectin receptor, integrin alpha8beta1 is decreased in the lung mesenchyme in the same inflammation model suggesting it is ...[more]
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