MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines.
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ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC2783372 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines.
Liu Xiqiang X Jiang Lu L Wang Anxun A Yu Jinsheng J Shi Fei F Zhou Xiaofeng X
Cancer letters 20090621 2
Metastasis is a critical event in the progression of head and neck squamous cell carcinoma (HNSCC). To identify microRNAs associated with HNSCC metastasis, six paired HNSCC cell lines with different metastatic potential were examined. Using microarrays, a panel of differentially expressed microRNAs was identified, including reduction of miR-138 in highly metastatic cells. Ectopic transfection of miR-138 suppressed cell invasion and led to cell cycle arrest and apoptosis. Knockdown of miR-138 enh ...[more]
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