Quantifying biogenic bias in screening libraries.
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ABSTRACT:
SUBMITTER: Hert J
PROVIDER: S-EPMC2783405 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Quantifying biogenic bias in screening libraries.
Hert Jérôme J Irwin John J JJ Laggner Christian C Keiser Michael J MJ Shoichet Brian K BK
Nature chemical biology 20090531 7
In lead discovery, libraries of 10(6) molecules are screened for biological activity. Given the over 10(60) drug-like molecules thought possible, such screens might never succeed. The fact that they do, even occasionally, implies a biased selection of library molecules. We have developed a method to quantify the bias in screening libraries toward biogenic molecules. With this approach, we consider what is missing from screening libraries and how they can be optimized. ...[more]
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