Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block.
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ABSTRACT:
SUBMITTER: Cao H
PROVIDER: S-EPMC2783551 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block.
Cao Hongzhi H Huang Shengshu S Cheng Jiansong J Li Yanhong Y Muthana Saddam S Son Bryan B Chen Xi X
Carbohydrate research 20080704 17
The sialyl Lewis x tetrasaccharide with a propylamine aglycon was assembled by chemoselective glycosylation from a p-tolyl thioglycosyl donor obtained from an enzymatically synthesized sialodisaccharide. Combining the advantages of highly efficient enzymatic synthesis of sialoside building blocks, and diverse chemical glycosylation, this chemoenzymatic approach is practical for obtaining complex sialosides and their analogues. ...[more]
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