Ontology highlight
ABSTRACT:
SUBMITTER: Ding W
PROVIDER: S-EPMC2783570 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
British journal of haematology 20090908 4
It was hypothesized that contact between chronic lymphocytic leukaemia (CLL) B-cells and marrow stromal cells impact both cell types. To test this hypothesis, we utilized a long-term primary culture system from bone biopsies that reliably generates a mesenchymal stem cell (MSC). Co-culture of MSC with CLL B-cells protected the latter from both spontaneous apoptosis and drug-induced apoptosis. The CD38 expression in previously CD38 positive CLL B-cells was up-regulated with MSC co-culture. Upregu ...[more]