Ontology highlight
ABSTRACT:
SUBMITTER: Gaudet MM
PROVIDER: S-EPMC2783691 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Gaudet Mia M MM Campan Mihaela M Figueroa Jonine D JD Yang Xiaohong R XR Lissowska Jolanta J Peplonska Beata B Brinton Louise A LA Rimm David L DL Laird Peter W PW Garcia-Closas Montserrat M Sherman Mark E ME
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20091027 11
Improved understanding of the etiology of estrogen receptor-alpha (ERalpha)-negative and progesterone receptor (PR)-negative breast cancers may permit improved risk prediction. In vitro studies implicate DNA hypermethylation of the ERalpha and PR promoters in the pathogenesis of ERalpha-negative and PR-negative tumors, but results are not definitive. We evaluated 200 invasive breast cancers selected from a population-based case-control study. DNA extracted from fixed tumor tissue cores was teste ...[more]