Ontology highlight
ABSTRACT:
SUBMITTER: Nicolaou KC
PROVIDER: S-EPMC2783699 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20091101 46
Platensimycin is the flagship member of a new and growing class of antibiotics with promising antibacterial properties against drug-resistant bacteria. The total syntheses of platensimycin and its congeners, platensimycins B(1) and B(3), platensic acid, methyl platensinoate, platensimide A, homoplatensimide A, and homoplatensimide A methyl ester, are described. The convergent strategy developed toward these target molecules involved construction of their cage-like core followed by attachment of ...[more]