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Palladium- and copper-catalyzed solution phase synthesis of a diverse library of isoquinolines.

ABSTRACT: The solution-phase synthesis of a 111 member isoquinoline library is described. The isoquinoline scaffold has been accessed through the palladium- and copper-catalyzed cyclization of iminoalkynes and the palladium-catalyzed iminoannulation of internal alkynes, followed by diversification of hydroxyl functionality where it is present.

SUBMITTER: Roy S

PROVIDER: S-EPMC2783704 | biostudies-literature | 2009 Nov-Dec

REPOSITORIES: biostudies-literature

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Palladium- and copper-catalyzed solution phase synthesis of a diverse library of isoquinolines.

Roy Sudipta S Roy Sujata S Neuenswander Benjamin B Hill David D Larock Richard C RC

Journal of combinatorial chemistry 20091101 6

The solution-phase synthesis of a 111 member isoquinoline library is described. The isoquinoline scaffold has been accessed through the palladium- and copper-catalyzed cyclization of iminoalkynes and the palladium-catalyzed iminoannulation of internal alkynes, followed by diversification of hydroxyl functionality where it is present. ...[more]

PMID: 19728736

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