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Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis.

ABSTRACT: The sequential steps of neurogenesis are characterized by highly choreographed changes in transcription factor activity. In contrast to the well-studied mechanisms of transcription factor activation during neurogenesis, much less is understood regarding how such activity is terminated. We previously showed that MTGR1, a member of the MTG family of transcriptional repressors, is strongly induced by a proneural basic helix-loop-helix transcription factor, NEUROG2 in developing nervous system. In this study, we describe a novel feedback regulation of NEUROG2 activity by MTGR1. We show that MTGR1 physically interacts with NEUROG2 and represses transcriptional activity of NEUROG2. MTGR1 also prevents DNA binding of the NEUROG2/E47 complex. In addition, we provide evidence that proper termination of NEUROG2 activity by MTGR1 is necessary for normal progression of neurogenesis in the developing spinal cord. These results highlight the importance of feedback regulation of proneural gene activity in neurodevelopment.

SUBMITTER: Aaker JD

PROVIDER: S-EPMC2783839 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis.

Aaker Joshua D JD Patineau Andrea L AL Yang Hyun-Jin HJ Ewart David T DT Gong Wuming W Li Tongbin T Nakagawa Yasushi Y McLoon Steven C SC Koyano-Nakagawa Naoko N

Molecular and cellular neurosciences 20090728 4

The sequential steps of neurogenesis are characterized by highly choreographed changes in transcription factor activity. In contrast to the well-studied mechanisms of transcription factor activation during neurogenesis, much less is understood regarding how such activity is terminated. We previously showed that MTGR1, a member of the MTG family of transcriptional repressors, is strongly induced by a proneural basic helix-loop-helix transcription factor, NEUROG2 in developing nervous system. In t ...[more]

PMID: 19646530

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Dataset Information

Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis.

Publications

Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis.

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