Synthesis and combinational antibacterial study of 5''-modified neomycin.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC2783947 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
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Synthesis and combinational antibacterial study of 5''-modified neomycin.
Zhang Jianjun J Keller Katherine K Takemoto Jon Y JY Bensaci Mekki M Litke Anthony A Czyryca Przemyslaw Greg PG Chang Cheng-Wei Tom CW
The Journal of antibiotics 20090724 10
A library of 5''-modified neomycin derivatives were synthesized for an antibacterial structure-activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities were measured when combined with other clinically used antibiotics. Significant synergistic activities were observed, which may lead to the development of novel therapeutic practices in the battle agai ...[more]
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