Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents.
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ABSTRACT:
SUBMITTER: Chennamaneni NK
PROVIDER: S-EPMC2783978 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
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Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents.
Chennamaneni Naveen Kumar NK Arif Jenifer J Buckner Frederick S FS Gelb Michael H MH
Bioorganic & medicinal chemistry letters 20091013 23
We developed a synthetic route to prepare isoquinoline analogs of the cancer drug clinical candidate tipifarnib. We show that these compounds kill Trypanosoma cruzi amastigotes grown in mammalian host cells at concentrations in the low nanomolar range. These isoquinolines represent new leads for the development of drugs to treat Chagas disease. ...[more]
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