Ontology highlight
ABSTRACT:
SUBMITTER: Matarin M
PROVIDER: S-EPMC2784015 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Matarin Mar M Brown W Mark WM Dena Hernandez H Britton Angela A De Vrieze Fabienne Wavrant FW Brott Thomas G TG Brown Robert D RD Worrall Bradford B BB Case L Douglas LD Chanock Stephen J SJ Metter E Jeffrey EJ Ferrucci Luigi L Gamble Dale D Hardy John A JA Rich Stephen S SS Singleton Andrew A Meschia James F JF
Stroke 20090903 11
<h4>Background and purpose</h4>Ischemic stroke (IS) is a multifactorial disorder with strong evidence from twin, family, and animal model studies suggesting a genetic influence on risk and prognosis. Several candidate genes for IS have been proposed, but few have been replicated. We investigated the contribution of 67 candidate genes (369 single nucleotide polymorphisms [SNPs]) on the risk of IS in a North American population of European descent.<h4>Methods</h4>Two independent studies were perfo ...[more]