Ontology highlight
ABSTRACT:
SUBMITTER: Voruganti VS
PROVIDER: S-EPMC2784272 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Voruganti V Saroja VS Göring Harald H H HH Mottl Amy A Franceschini Nora N Haack Karin K Laston Sandra S Almasy Laura L Fabsitz Richard R RR Lee Elisa T ET Best Lyle G LG Devereux Richard B RB Howard Barbara V BV MacCluer Jean W JW Comuzzie Anthony G AG Umans Jason G JG Cole Shelley A SA
Human genetics 20090710 5
Hyperuricemia is associated with the metabolic syndrome, gout, renal and cardiovascular disease (CVD). American Indians have high rates of CVD and 25% of individuals in the strong heart family study (SHFS) have high serum uric acid levels. The aim of this study was to investigate the genetic determinants of serum uric acid variation in American Indian participants of the SHFS. A variance component decomposition approach (implemented in SOLAR) was used to conduct univariate genetic analyses in ea ...[more]