Treatment of candidemia and invasive candidiasis in the intensive care unit: post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin B.
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ABSTRACT:
SUBMITTER: Dupont BF
PROVIDER: S-EPMC2784386 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
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Treatment of candidemia and invasive candidiasis in the intensive care unit: post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin B.
Dupont Bertrand F BF Lortholary Olivier O Ostrosky-Zeichner Luis L Stucker Flavie F Yeldandi Vijay V
Critical care (London, England) 20091005 5
<h4>Introduction</h4>Invasive candidiasis and candidemia are life-threatening nosocomial infections in intensive care patients.<h4>Methods</h4>A post hoc analysis of a phase 3 trial assessing micafungin (100 mg/day for subjects > 40 kg; 2 mg/kg/day for subjects <or= 40 kg) versus liposomal amphotericin B (3 mg/kg/day). Subgroups were defined according to the type of ward on the first day of treatment: intensive care unit (ICU) or non-ICU. Multivariate regression was performed to identify factors ...[more]
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