Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.
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ABSTRACT:
SUBMITTER: Baye TM
PROVIDER: S-EPMC2784739 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.
Baye Tes M TM Zhang Yi Y Smith Edward E Hillard Cecilia J CJ Gunnell Jennifer J Myklebust Joel J James Roland R Kissebah Ahmed H AH Olivier Michael M Wilke Russell A RA
Pharmacogenomics 20081101 11
<h4>Aims</h4>In humans, genetic variation in endocannabinergic signaling has been associated with anthropometric measures of obesity. In randomized trials, pharmacological blockade at the level of the cannabinoid receptor 1 (CNR1) receptor not only facilitates weight reduction, but also improves insulin sensitivity and clinical measures of lipid homeostasis. We therefore tested the hypothesis that genetic variation in CNR1 is associated with common obesity-related metabolic disorders.<h4>Materia ...[more]
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