Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC2784891 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Li Xuan X Stith Carrie M CM Burgers Peter M PM Heyer Wolf-Dietrich WD
Molecular cell 20091101 4
Genetic recombination ensures proper chromosome segregation during meiosis and is essential for genome stability and tumor suppression. DNA synthesis after Rad51-mediated DNA strand invasion is a crucial step during recombination. PCNA is known as the processivity clamp for DNA polymerases. Here, we report the surprising observation that PCNA is specifically required to initiate recombination-associated DNA synthesis in the extension of the 3' end of the invading strand in a D loop. We show usin ...[more]