Ontology highlight
ABSTRACT:
SUBMITTER: Yuan J
PROVIDER: S-EPMC2784992 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Yuan Jing J Johnson Ronald L RL Huang Ruili R Wichterman Jennifer J Jiang Hongying H Hayton Karen K Fidock David A DA Wellems Thomas E TE Inglese James J Austin Christopher P CP Su Xin-zhuan XZ
Nature chemical biology 20090906 10
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were active in inhibiting parasite growth; 607 differential chemical phenotypes, defined as pairwise IC(50) differences of fivefold or more between parasite lines, were cataloged. We mapped major d ...[more]