Ontology highlight
ABSTRACT:
SUBMITTER: Mans J
PROVIDER: S-EPMC2785082 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Mans Janet J Zhi Li L Revilleza Maria Jamela R MJ Smith Lee L Redwood Alec A Natarajan Kannan K Margulies David H DH
Immunologic research 20090101 1-3
The mouse cytomegalovirus (CMV), a beta-herpesvirus, exploits its large (~230 kb) double-stranded DNA genome for both essential and non-essential functions. Among the non-essential functions are those that offer the virus a selective advantage in eluding both the innate and adaptive immune responses of the host. Several non-essential genes of MCMV are thought to encode MHC-I-like genes and to function as immunoevasins. To understand further the evolution and function of these viral MHC-I (MHC-Iv ...[more]