Ontology highlight
ABSTRACT:
SUBMITTER: Han Y
PROVIDER: S-EPMC2785185 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20091008 48
The formin protein formin-like 1 (FMNL1) is highly restrictedly expressed in hematopoietic lineage-derived cells and has been previously identified as a tumor-associated antigen. However, function and regulation of FMNL1 are not well defined. We have identified a novel splice variant (FMNL1gamma) containing an intron retention at the C terminus affecting the diaphanous autoinhibitory domain (DAD). FMNL1gamma is specifically located at the cell membrane and cortex in diverse cell lines. Similar l ...[more]