Ontology highlight
ABSTRACT:
SUBMITTER: Chuang HH
PROVIDER: S-EPMC2785298 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Chuang Huai-hu HH Lin Stephanie S
Proceedings of the National Academy of Sciences of the United States of America 20091106 47
The capsaicin receptor TRPV1, one of the major transduction channels in the pain pathway, integrates information from extracellular milieu to control excitability of primary nociceptive neurons. Sensitization of TRPV1 heightens pain sensation to moderately noxious or even innocuous stimuli. We report here that oxidative stress markedly sensitizes TRPV1 in multiple species' orthologs. The sensitization can be recapitulated in excised inside-out membrane patches, reversed by strong reducing agents ...[more]