Role of mammalian Ecdysoneless in cell cycle regulation.
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ABSTRACT:
SUBMITTER: Kim JH
PROVIDER: S-EPMC2785328 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Role of mammalian Ecdysoneless in cell cycle regulation.
Kim Jun Hyun JH Gurumurthy Channabasavaiah Basavaraju CB Naramura Mayumi M Zhang Ying Y Dudley Andrew T AT Doglio Lynn L Band Hamid H Band Vimla V
The Journal of biological chemistry 20090729 39
The Ecdysoneless (Ecd) protein is required for cell-autonomous roles in development and oogenesis in Drosophila, but the function of its evolutionarily conserved mammalian orthologs is not clear. To study the cellular function of Ecd in mammalian cells, we generated Ecd(lox/lox) mouse embryonic fibroblast cells from Ecd floxed mouse embryos. Cre-mediated deletion of Ecd in Ecd(lox/lox) mouse embryonic fibroblasts led to a proliferative block due to a delay in G(1)-S cell cycle progression; this ...[more]
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