Ontology highlight
ABSTRACT:
SUBMITTER: Cazanave SC
PROVIDER: S-EPMC2785347 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Cazanave Sophie C SC Mott Justin L JL Elmi Nafisa A NA Bronk Steven F SF Werneburg Nathan W NW Akazawa Yuko Y Kahraman Alisan A Garrison Sean P SP Zambetti Gerard P GP Charlton Michael R MR Gores Gregory J GJ
The Journal of biological chemistry 20090728 39
Free fatty acids (FFA) induce hepatocyte lipoapoptosis by a c-Jun N-terminal kinase (JNK)-dependent mechanism. However, the cellular processes by which JNK engages the core apoptotic machinery during lipotoxicity, especially activation of BH3-only proteins, remain incompletely understood. Thus, our aim was to determine whether JNK mediates induction of BH3-only proteins during hepatocyte lipoapoptosis. The saturated FFA palmitate, but not the monounsaturated FFA oleate, induces an increase in PU ...[more]