Ontology highlight
ABSTRACT:
SUBMITTER: Zhao L
PROVIDER: S-EPMC2785384 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Zhao Lequn L Dong Hongyun H Zhang Cheng Cheng CC Kinch Lisa L Osawa Mitsujiro M Iacovino Michelina M Grishin Nikolai V NV Kyba Michael M Huang Lily Jun-shen LJ
The Journal of biological chemistry 20090728 39
JAK2 (Janus kinase 2) is essential for cytokine receptor signaling, and several lines of evidence support a causal role of an activating JAK2 mutation in myeloproliferative disorders. JAK2 activity is autoinhibited by its pseudokinase domain in the basal state, and the inhibition is released by cytokine stimulation; how engagement of the cognate receptor triggers this release is unknown. From a functional screen for gain-of-function JAK2 mutations, we discovered 13 missense mutations, nine in th ...[more]