Ontology highlight
ABSTRACT:
SUBMITTER: Williams DR
PROVIDER: S-EPMC2785454 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20090701 25
The stereocontrolled total synthesis of 4-hydroxydictyolactone (4), a member of the xenicane diterpene family of natural products, is described. These studies feature the development of the B-alkyl Suzuki cross-coupling reaction for direct access to (E)-cyclononenes from acyclic precursors. The Ireland-Claisen rearrangement is effectively utilized to establish the backbone asymmetry of the contiguous C(2), C(3), C(10) stereotriad of 4. The synthesis strategy has devised an intramolecular Nozaki- ...[more]