Ontology highlight
ABSTRACT:
SUBMITTER: Yue J
PROVIDER: S-EPMC2785564 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Yue Jianbo J Wei Wenjie W Lam Connie M C CM Zhao Yong-Juan YJ Dong Min M Zhang Liang-Ren LR Zhang Li-He LH Lee Hon-Cheung HC
The Journal of biological chemistry 20090820 43
Intracellular Ca(2+) mobilization plays an important role in a wide variety of cellular processes, and multiple second messengers are responsible for mediating intracellular Ca(2+) changes. Here we explored the role of one endogenous Ca(2+)-mobilizing nucleotide, cyclic adenosine diphosphoribose (cADPR), in the proliferation and differentiation of neurosecretory PC12 cells. We found that cADPR induced Ca(2+) release in PC12 cells and that CD38 is the main ADP-ribosyl cyclase responsible for the ...[more]