Ontology highlight
ABSTRACT:
SUBMITTER: Gell DA
PROVIDER: S-EPMC2785579 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Gell David A DA Feng Liang L Zhou Suiping S Jeffrey Philip D PD Bendak Katerina K Gow Andrew A Weiss Mitchell J MJ Shi Yigong Y Mackay Joel P JP
The Journal of biological chemistry 20090825 43
alpha-Hemoglobin (alphaHb) stabilizing protein (AHSP) is expressed in erythropoietic tissues as an accessory factor in hemoglobin synthesis. AHSP forms a specific complex with alphaHb and suppresses the heme-catalyzed evolution of reactive oxygen species by converting alphaHb to a conformation in which the heme is coordinated at both axial positions by histidine side chains (bis-histidyl coordination). Currently, the detailed mechanism by which AHSP induces structural changes in alphaHb has not ...[more]