Ontology highlight
ABSTRACT:
SUBMITTER: Narasimhachar Y
PROVIDER: S-EPMC2785651 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Narasimhachar Yadushyla Y Coué Martine M
The Journal of biological chemistry 20090805 40
During the mitotic cell cycle, Geminin can act both as a promoter and inhibitor of initiation of DNA replication. As a promoter, Geminin stabilizes Cdt1 and facilitates its accumulation leading to the assembly of the pre-replication complex on DNA. As an inhibitor, Geminin prevents Cdt1 from loading the mini-chromosome maintenance complex onto pre-replication complexes in late S, G(2), and M phases. Here we show that during meiosis Geminin functions as a stabilizer of Cdt1 promoting its accumula ...[more]