Ontology highlight
ABSTRACT:
SUBMITTER: Alencastre IS
PROVIDER: S-EPMC2785652 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Alencastre Inês S IS Rodrigues Tony A TA Grou Cláudia P CP Fransen Marc M Sá-Miranda Clara C Azevedo Jorge E JE
The Journal of biological chemistry 20090723 40
Newly synthesized peroxisomal matrix proteins are targeted to the organelle by PEX5, the peroxisomal cycling receptor. Over the last few years, valuable data on the mechanism of this process have been obtained using a PEX5-centered in vitro system. The data gathered until now suggest that cytosolic PEX5.cargo protein complexes dock at the peroxisomal docking/translocation machinery, where PEX5 becomes subsequently inserted in an ATP-independent manner. This PEX5 species is then monoubiquitinated ...[more]