PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene.
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ABSTRACT:
SUBMITTER: Mascarenhas JB
PROVIDER: S-EPMC2785681 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene.
Mascarenhas Joseph B JB Young Kacey P KP Littlejohn Erica L EL Yoo Brian K BK Salgia Ravi R Lang Deborah D
The Journal of biological chemistry 20090803 40
Tumors of the exocrine pancreas have a poor prognosis. Several proteins are overexpressed in this cancer type, including the MET tyrosine kinase receptor and the transcription factor PAX6. In this report, we find that PAX6(5a), an alternately spliced variant form of PAX6, is expressed in pancreatic carcinoma cell lines at higher levels than the canonical PAX6 protein. Both protein forms of PAX6 bind directly to an enhancer element in the MET promoter and activate the expression of the MET gene. ...[more]
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