Ontology highlight
ABSTRACT:
SUBMITTER: Lee A
PROVIDER: S-EPMC2785851 | biostudies-literature | 2009 May-Jun
REPOSITORIES: biostudies-literature
Channels (Austin, Tex.) 20090524 3
Voltage-gated sodium channels are membrane proteins that initiate action potentials in neurons following membrane depolarization. Members of this family show differential distribution at the subcellular level. The mechanisms underlying the targeting of these isoforms are not understood. However, their specificity is important because the isoforms can change the excitability of the membrane due to differences in their electrophysiological properties. In this study, chimeras generated between Na(V ...[more]