Pharmacological treatment for heart failure: a view from the brain.
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ABSTRACT:
SUBMITTER: Felder RB
PROVIDER: S-EPMC2786214 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Pharmacological treatment for heart failure: a view from the brain.
Felder R B RB Yu Y Y Zhang Z-H ZH Wei S-G SG
Clinical pharmacology and therapeutics 20090624 2
Systolic heart failure is a feed-forward phenomenon with devastating consequences. Impaired cardiac function is the initiating event, but central nervous system mechanisms activated by persistent altered neural and humoral signals from the periphery play an important sustaining role. Animals with experimentally induced heart failure have neurochemical abnormalities in the brain that, when manipulated, profoundly affect sympathetic drive, volume regulation, and cardiac remodeling--critical determ ...[more]
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