Characterization of a Campylobacter jejuni VirK protein homolog as a novel virulence determinant.
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SUBMITTER: Novik V
PROVIDER: S-EPMC2786475 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
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Characterization of a Campylobacter jejuni VirK protein homolog as a novel virulence determinant.
Novik Veronica V Hofreuter Dirk D Galán Jorge E JE
Infection and immunity 20090921 12
Campylobacter jejuni is a leading cause of food-borne illness in the United States. Despite significant recent advances, its mechanisms of pathogenesis are poorly understood. A unique feature of this pathogen is that, with some exceptions, it lacks homologs of known virulence factors from other pathogens. Through a genetic screen, we have identified a C. jejuni homolog of the VirK family of virulence factors, which is essential for antimicrobial peptide resistance and mouse virulence. ...[more]
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