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A typhus group-specific protease defies reductive evolution in rickettsiae.


ABSTRACT: Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (ppcE) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, ppcE warrants consideration in the development of therapeutics against epidemic and murine typhus.

SUBMITTER: Ammerman NC 

PROVIDER: S-EPMC2786609 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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A typhus group-specific protease defies reductive evolution in rickettsiae.

Ammerman Nicole C NC   Gillespie Joseph J JJ   Neuwald Andrew F AF   Sobral Bruno W BW   Azad Abdu F AF  

Journal of bacteriology 20091009 24


Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (ppcE) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, ppcE warrants consideration in the development of therapeutics against epidemic and murine typhus. ...[more]

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