Evaluation of hepatitis C virus core antigen assays in detecting recombinant viral antigens of various genotypes.
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ABSTRACT:
SUBMITTER: Saeed M
PROVIDER: S-EPMC2786616 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
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Evaluation of hepatitis C virus core antigen assays in detecting recombinant viral antigens of various genotypes.
Saeed Mohsan M Suzuki Ryosuke R Kondo Madoka M Aizaki Hideki H Kato Takanobu T Mizuochi Toshiaki T Wakita Takaji T Watanabe Haruo H Suzuki Tetsuro T
Journal of clinical microbiology 20091007 12
A single substitution within the hepatitis C virus core antigen sequence, A48T, which is observed in approximately 30% of individuals infected with genotype 2a virus, reduces the sensitivity of a commonly used chemiluminescence enzyme immunoassay. Quantitation of the antigen is improved by using a distinct anticore antibody with a different epitope. ...[more]
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