Ontology highlight
ABSTRACT:
SUBMITTER: Volle DH
PROVIDER: S-EPMC2786790 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Volle David H DH Decourteix Mélanie M Garo Erwan E McNeilly Judy J Fenichel Patrick P Auwerx Johan J McNeilly Alan S AS Schoonjans Kristina K Benahmed Mohamed M
The Journal of clinical investigation 20091102 12
Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol (DES). Although the molecular basis for this effect remains unknown, estrogen receptors likely play a critical role in mediating DES-induced infertility. Recently, we showed that the orphan nuclear receptor small heterodimer partner (Nr0b2), which is both a target gene and a trans ...[more]