Ontology highlight
ABSTRACT:
SUBMITTER: Alam SM
PROVIDER: S-EPMC2787149 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Alam S Munir SM Morelli Marco M Dennison S Moses SM Liao Hua-Xin HX Zhang Ruijun R Xia Shi-Mao SM Rits-Volloch Sophia S Sun Li L Harrison Stephen C SC Haynes Barton F BF Chen Bing B
Proceedings of the National Academy of Sciences of the United States of America 20091111 48
Induction of effective antibody responses against HIV-1 infection remains an elusive goal for vaccine development. Progress may require in-depth understanding of the molecular mechanisms of neutralization by monoclonal antibodies. We have analyzed the molecular actions of two rare, broadly neutralizing, human monoclonal antibodies, 4E10 and 2F5, which target the transiently exposed epitopes in the membrane proximal external region (MPER) of HIV-1 gp41 envelope during viral entry. Both have long ...[more]