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FAS promoter polymorphism: outcome of childhood acute myeloid leukemia. A children's oncology group report.

ABSTRACT: FAS is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in down-regulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism resulting in guanine-to-adenine transition in the FAS promoter region (position -1377) is thought to reduce stimulatory protein 1 transcription factor binding and decrease FAS expression. Previous work has shown increased risk of developing acute myeloid leukemia (AML) in adult patients with a variant allele at this site. The same authors have shown that the presence of an adenine residue rather than a guanine residue at -1,377 bp significantly attenuates transcription factor stimulatory protein 1 binding and may contribute to a reduction in FAS expression and ultimately to the enrichment of apoptosis-resistant clones in AML. We hypothesized that FAS genotype by altering susceptibility to apoptosis might affect outcome of childhood AML therapy.Four hundred forty-four children treated for de novo AML on a uniform protocol were genotyped for FAS 1377.There were no significant differences in overall survival, event-free survival, treatment-related mortality, or relapse rate between patients with FAS 1377GG genotype versus 1377GA/1377AA genotypes.FAS 1377 genotype does not alter outcome of de novo AML in children.

SUBMITTER: Mehta PA

PROVIDER: S-EPMC2787450 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature

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FAS promoter polymorphism: outcome of childhood acute myeloid leukemia. A children's oncology group report.

Mehta Parinda A PA Gerbing Robert B RB Alonzo Todd A TA Elliott James S JS Zamzow Tiffany A TA Combs Michelle M Stover Emily E Ross Julie A JA Perentesis John P JP Meschinchi Soheil S Lange Beverly J BJ Davies Stella M SM

Clinical cancer research : an official journal of the American Association for Cancer Research 20081201 23

<h4>Purpose</h4>FAS is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in down-regulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism resulting in guanine-to-adenine transition in the FAS promoter region (position -1377) is thought to reduce stimulatory protein 1 transcription factor binding and decrease FAS expression. Previous work has shown increased risk of developing acute myeloid leuk ...[more]

PMID: 19047119

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Dataset Information

FAS promoter polymorphism: outcome of childhood acute myeloid leukemia. A children's oncology group report.

Publications

FAS promoter polymorphism: outcome of childhood acute myeloid leukemia. A children's oncology group report.

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