Ontology highlight
ABSTRACT:
SUBMITTER: Datwani A
PROVIDER: S-EPMC2787480 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Datwani Akash A McConnell Michael J MJ Kanold Patrick O PO Micheva Kristina D KD Busse Brad B Shamloo Mehrdad M Smith Stephen J SJ Shatz Carla J CJ
Neuron 20091101 4
Major histocompatibility complex class I (MHCI) genes were discovered unexpectedly in healthy CNS neurons in a screen for genes regulated by neural activity. In mice lacking just 2 of the 50+ MHCI genes H2-K(b) and H2-D(b), ocular dominance (OD) plasticity is enhanced. Mice lacking PirB, an MHCI receptor, have a similar phenotype. H2-K(b) and H2-D(b) are expressed not only in visual cortex, but also in lateral geniculate nucleus (LGN), where protein localization correlates strongly with synaptic ...[more]