Ontology highlight
ABSTRACT:
SUBMITTER: Khalsa SS
PROVIDER: S-EPMC2787640 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Nature neuroscience 20091101 12
A network of cortical brain regions, including the insula and anterior cingulate cortex (ACC), has been proposed as the critical and sole substrate for interoceptive awareness. Combining lesion and pharmacological approaches in humans, we found that the insula and ACC were not critical for awareness of heartbeat sensations. Instead, this awareness was mediated by both somatosensory afferents from the skin and a network that included the insula and ACC. Together, these pathways enable the core hu ...[more]