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Improved method for the synthesis of beta-carbonyl silyl-1,3-dithianes by the double conjugate addition of 1,3-dithiol to propargylic carbonyl compounds.

ABSTRACT: Base-mediated double conjugate addition of 1,3-propane dithiol to various silylated propargylic aldehydes and ketones allows for an efficient and scalable synthesis of beta-carbonyl silyl-1,3-dithianes.

SUBMITTER: Mukherjee S

PROVIDER: S-EPMC2787704 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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Improved method for the synthesis of beta-carbonyl silyl-1,3-dithianes by the double conjugate addition of 1,3-dithiol to propargylic carbonyl compounds.

Mukherjee Sumit S Kontokosta Dimitra D Patil Aditi A Rallapalli Sivakumar S Lee Daesung D

The Journal of organic chemistry 20091201 23

Base-mediated double conjugate addition of 1,3-propane dithiol to various silylated propargylic aldehydes and ketones allows for an efficient and scalable synthesis of beta-carbonyl silyl-1,3-dithianes. ...[more]

PMID: 19877611

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Dynamic thiol exchange with ?-sulfido-?,?-unsaturated carbonyl compounds and dithianes.

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2,5-Bis(1,3-dithiol-2-yl-idene)-1,3-dithiol-ane-4-thione.

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