A low molecular weight PSMA-based fluorescent imaging agent for cancer.
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ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC2787846 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
A low molecular weight PSMA-based fluorescent imaging agent for cancer.
Chen Ying Y Dhara Surajit S Banerjee Sangeeta Ray SR Byun Youngjoo Y Pullambhatla Mrudula M Mease Ronnie C RC Pomper Martin G MG
Biochemical and biophysical research communications 20091008 3
We synthesized YC-27 3 to provide a fluorescent imaging agent for the prostate-specific membrane antigen (PSMA), a marker for hormone-independent prostate cancer and tumor neovasculature, with suitable pharmacokinetics for use in vivo. Immediate precursor trifluoroacetate salt of 2-(3-{5-[7-(5-amino-1-carboxy-pentylcarbamoyl)-heptanoylamino]-1-carboxy-pentyl}-ureido)-pentanedioic acid 2 was conjugated with a commercially available near-infrared light-emitting dye (IRDye 800CW) to provide 3 in 72 ...[more]
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