Ontology highlight
ABSTRACT:
SUBMITTER: Mamolen M
PROVIDER: S-EPMC2787996 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Mamolen Megan M Andrulis Erik D ED
Biochemical and biophysical research communications 20091002 3
The Dis3 ribonuclease is a member of the hydrolytic RNR protein family. Although much progress has been made in understanding the structure, function, and enzymatic activities of prokaryotic RNR family members RNase II and RNase R, there are no activity studies of the metazoan ortholog, Dis3. Here, we characterize the activity of the Drosophila melanogaster Dis3 (dDis3) protein. We find that dDis3 is active in the presence of various monovalent and divalent cations, and requires divalent cations ...[more]