Ontology highlight
ABSTRACT:
SUBMITTER: Qu H
PROVIDER: S-EPMC2788007 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Qu Hongchang H Ricklin Daniel D Lambris John D JD
Molecular immunology 20091002 2-3
As a key part of the innate immune system, complement plays an important role not only in defending against invading pathogens but also in many other biological processes. Inappropriate or excessive activation of complement has been linked to many autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer. A wide array of low molecular weight complement inhibitors has been developed to target various components of the complement cascade. Their eff ...[more]